Genetic Disease Transmission Probability

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Autosomal Recessive Diseases:

Probability that a child will inherit an autosomal recessive disease is calculated as:

[probability that dad is carrier]

multiplied by

[probability that mom is carrier]

multiplied by

[probability that dad transmits disease to child; this value is 1 if dad has the disease]

multiplied by

[probability that mom transmits disease to child; this value is 1 if mom has the disease].

X-Linked Recessive Disease:

Probability that a child will inherit an X-linked recessive disease is calculated as:

[probability that dad is carrier]

multiplied by

[probability that mom is carrier]

multiplied by

[probability that dad transmits disease to child]

multiplied by

[probability that mom transmits disease to child].

multiplied by

[probability that child is either male or female]

Additional Readings:

Basic Genetics

1. Single-Gene Disorders
2. Population Genetics
3. Genetic Disease Transmission Probability
4. What is Cytogenetics?
5. Notes on Bloom's Syndrome
6. Introduction to Human Chromosomes
7. Life Cycle of Somatic Cells

Related Topics

1. Genetic and Developmental Disorders
2. Genetic Code, Mutations, and Translation

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