What is Steady State Concentration?

  >   Rahul's Noteblog   >   Notes on Pharmacology   >   What is Steady State Concentration?

What is Steady State Concentration?

• Steady State concentration is eventually achieved when a drug is administered at a constant rate.

• A drug is administrated after a specific amount of time or a constant rate.

• During each interdose interval, the concentration of the drug rises and falls.

How to calculate Steady State Concentration?

steady state calculation equation

Where,

F = Fractional bioavailability of the dose. (in percentage %)

Dose in mg/70Kg.

CL = Clearance from systemic circulation. (in L/hr/70Kg)

T = dose interval (in hours).

The units of steady state concentration are mg/L

Related Formulas:

The product of clearance and concentration = rate of drug availability.

Dosing rate = clearance from systemic circulation x steady state concentration.

Clearance from systemic circulation = [rate of elimination] / [concentration].

Maintenance dose = [desired plasma concentration at steady state] x [clearance] / [bioavaliability of the drug].

NOTE: Medications obeying first-order kinetics reach steady-state concentration in 4-5 half-lives.

Additional Readings:

Basic Pharmacology

1. What is Steady State Concentration?
2. What is Blood-Gas Partition Coefficient?
3. Effects of Adrenergic Stimulation
4. Types of Antipsychotics

USMLE Pharmacology Flashcards

NOTE: Javascript must be enbled.

1. Cardiovascular Part 1
2. Cardiovascular Part 2
3. Endocrinology
4. Gastroenterology
5. Hematology and Oncology Part 1
6. Hematology and Oncology Part 2
7. Immunology
8. Microbiology Part 1
9. Microbiology Part 2
10. Microbiology Part 3
11. Musculoskeletal and Connective Tissue
12. Neurology
13. Psychiatry
14. Renal
15. Reproduction
16. Respiration

Random Pages:

One Powerful Prayer written by an Anonymous Author Body-Mass-Index, Waist-to-Height Ratio, Body Fat, Basal Metabolic Rate Calculator
Signs you`re being married to for Green Card Notes on Male Reproductive System
Notes on Osteology of Pectoral Region What is Botulism?
Notes on Pyruvate Metabolism Notes on Inferential Statistics
Synthesis and Deficiencies of Adrenal Hormones Notes on Types of Jaundice
Notes on Basic Gastrointestinal Physiology Inferential Statistics
Notes on Osteogenesis What is an ELEK`s Test?
Why did I decide to become a doctor? Medical School Admissions Essay Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies Video of me playing Hagood Hardy`s "The Homecoming"
Notes on Female Reproductive System Differentiation and Anatomy of a Blastocyst
Notes on Cell Components Notes on Nervous Tissue
Voices from Hell: My Experience in Mussoorie, India Video of Cardiology Examination in a Clinical Setting

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.