What is Steady State Concentration?

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What is Steady State Concentration?

• Steady State concentration is eventually achieved when a drug is administered at a constant rate.

• A drug is administrated after a specific amount of time or a constant rate.

• During each interdose interval, the concentration of the drug rises and falls.

How to calculate Steady State Concentration?

steady state calculation equation


F = Fractional bioavailability of the dose. (in percentage %)

Dose in mg/70Kg.

CL = Clearance from systemic circulation. (in L/hr/70Kg)

T = dose interval (in hours).

The units of steady state concentration are mg/L

Related Formulas:

The product of clearance and concentration = rate of drug availability.

Dosing rate = clearance from systemic circulation x steady state concentration.

Clearance from systemic circulation = [rate of elimination] / [concentration].

Maintenance dose = [desired plasma concentration at steady state] x [clearance] / [bioavaliability of the drug].

NOTE: Medications obeying first-order kinetics reach steady-state concentration in 4-5 half-lives.

Additional Readings:

Basic Pharmacology

1. What is Steady State Concentration?
2. What is Blood-Gas Partition Coefficient?
3. Effects of Adrenergic Stimulation
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USMLE Pharmacology Flashcards

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