What is Steady State Concentration?
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Notes on Pharmacology
What is Steady State Concentration?
What is Steady State Concentration?
• Steady State concentration is eventually achieved when a drug is administered at a constant rate.
• A drug is administrated after a specific amount of time or a constant rate.
• During each interdose interval, the concentration of the drug rises and falls.
How to calculate Steady State Concentration?
Where,
F = Fractional bioavailability of the dose. (in percentage %)
Dose in mg/70Kg.
CL = Clearance from systemic circulation. (in L/hr/70Kg)
T = dose interval (in hours).
The units of steady state concentration are mg/L
Related Formulas:
The product of clearance and concentration = rate of drug availability.
Dosing rate = clearance from systemic circulation x steady state concentration.
Clearance from systemic circulation = rate of elimination divided into concentration.
Additional Readings:
Basic Pharmacology
1. What is Steady State Concentration?
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