Notes on Human Immunodeficiency Virus

  >   Rahul's Noteblog   >   Notes on Virology   >   Notes on Human Immunodeficiency Virus

Human Immunodeficiency Virus:

• Positive-sense; ssRNA virus.

HIV Viral Genes:

Gag: structural proteins like p24 and p7.

Pol: reverse transcriptase/integrase/protease.

Env: gp120 and gp41.

Tat: upregulator of transcription.

Rev: upregulator of transport of products of transcription to cytoplasm.

Nef: downregulator.

Summary of HIV Infection:

1. gp120 binds CD4 of TH cells/macrophages/microglia.

2. HIV taken into cell; RNA uncoated.

3. dsDNA made from RNA using reverse transcriptase.

4. dsDNA integrated into host DNA; provirus made; provirus remains in host DNA.

5. Transcription of host DNA also produces viral ss (+) RNAs.

6. New proteins made.

7. Assembly.

8. Maturation/release.

CDC categories:

A: acute or asymptomatic; persistent generalized lymphadenopathy.

B: symptomatic; candidiasis; hairy leukoplakia; PID; peripheral neuropathy; idiopathic thrombocytopenic purpura.

C: AIDS defining conditions; fungal/carcinomas/viral/parasitic/bacterial infections.

Diagnosis:

• Screening: ELISA.

• Confirmation: Western blot / immunofluorescence.

• Detection of infection in newborns of HIV+ moms: DNA/PCR.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs specialized transduction
10. Hepatitis serologic markers
11. Bacterial vs viral infections
12. Human Immunodeficiency Virus (HIV) Infections and AIDS
13. Steps When Patient is Newly Diagnosed with HIV

Related Topics

1. Prenatal Infections

Medical Images

Useful Medical Images & Diagrams (link opens in a new window)

Random Pages:

Voices from Hell: My Experience in Mussoorie, India Video of American Robin feeding her chicks
Video of me playing Unknown Easy Blues Piano Notes on Gastrointestinal System
Notes on Axillary Artery Aneurysm Notes on Actinomyces
Notes on Nitrogen Fixation (Metabolism) reactions, and Heme Metabolism Notes on Inferential Statistics
Synthesis and Deficiencies of Adrenal Hormones Notes on Hypothalamic-pituitary system
Notes on Basic Gastrointestinal Physiology Inferential Statistics
Notes on Osteogenesis What is an ELEK`s Test?
Why did I decide to become a doctor? Medical School Admissions Essay Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies Signs you`re being married to for Green Card
Notes on Male Reproductive System Differentiation and Anatomy of a Blastocyst
Notes on Cell Components Notes on Nervous Tissue
Voices from Hell: My Experience in Mussoorie, India Video of Cardiology Examination in a Clinical Setting

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.