Notes on Human Immunodeficiency Virus

  >   Rahul's Noteblog   >   Notes on Virology   >   Notes on Human Immunodeficiency Virus

Human Immunodeficiency Virus:

• Positive-sense; ssRNA virus.

HIV Viral Genes:

Gag: structural proteins like p24 and p7.

Pol: reverse transcriptase/integrase/protease.

Env: gp120 and gp41.

Tat: upregulator of transcription.

Rev: upregulator of transport of products of transcription to cytoplasm.

Nef: downregulator.

Summary of HIV Infection:

1. gp120 binds CD4 of TH cells/macrophages/microglia.

2. HIV taken into cell; RNA uncoated.

3. dsDNA made from RNA using reverse transcriptase.

4. dsDNA integrated into host DNA; provirus made; provirus remains in host DNA.

5. Transcription of host DNA also produces viral ss (+) RNAs.

6. New proteins made.

7. Assembly.

8. Maturation/release.

CDC categories:

A: acute or asymptomatic; persistent generalized lymphadenopathy.

B: symptomatic; candidiasis; hairy leukoplakia; PID; peripheral neuropathy; idiopathic thrombocytopenic purpura.

C: AIDS defining conditions; fungal/carcinomas/viral/parasitic/bacterial infections.

Diagnosis:

• Screening: ELISA.

• Confirmation: Western blot / immunofluorescence.

• Detection of infection in newborns of HIV+ moms: DNA/PCR.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs specialized transduction
10. Hepatitis serologic markers
11. Bacterial vs viral infections
12. Human Immunodeficiency Virus (HIV) Infections and AIDS
13. Steps When Patient is Newly Diagnosed with HIV

Related Topics

1. Prenatal Infections

Medical Images

Useful Medical Images & Diagrams (link opens in a new window)

Random Pages:

The Big Bang: Proof that the Universe is Expanding Video of American Robin feeding her chicks
Rahul`s Piano Music MP3 Collection Notes on Renal/Urinary System
Notes on Arteries of the Axilla Notes on Enterococcus
Notes on Pyruvate Metabolism What are the most common causes of aortic stenosis?
Differentiation of the Face FAQ on Gastric Digestion
Notes on Basic Gastrointestinal Physiology Voices from Hell: My Experience in Mussoorie, India
Review of Delta Roma Imperiale Fountain Pen What is an ELEK`s Test?
Why did I decide to become a doctor? Medical School Admissions Essay Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies Signs you`re being married to for Green Card
Notes on Muscle Tissue Differentiation and Anatomy of a Blastocyst
Notes on Cell Components Notes on Nervous Tissue
Voices from Hell: My Experience in Mussoorie, India Video of Cardiology Examination in a Clinical Setting

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.