Notes on Human Immunodeficiency Virus

  breadcrumb arrow   Rahul's Noteblog   breadcrumb arrow   Notes on Virology   breadcrumb arrow   Notes on Human Immunodeficiency Virus

Human Immunodeficiency Virus:

• Positive-sense; ssRNA virus.

Genes:
Gag: structural proteins.
Pol: reverse transcriptase/integrase/protease.
Env: gp120/gp41.
Tat: upregulator of transcription.
Rev: upregulator of transport of products of transcription to cytoplasm.
Nef: downregulator.

1. gp120 binds CD4 of TH cells/macrophages/microglia.
2. HIV taken into cell; RNA uncoated.
3. dsDNA made from RNA using reverse transcriptase.
4. dsDNA integrated into host DNA; provirus made; provirus remains in host DNA.
5. Transcription of host DNA also produces viral ss (+) RNAs.
6. New proteins made
7. Assembly.
8. Maturation/release.

CDC categories:
A: acute or asymptomatic; persistent generalized lymphadenopathy.

B: symptomatic; candidiasis; hairy leukoplakia; PID; peripheral neuropathy; idiopathic thrombocytopenic purpura.

C: AIDS defining conditions; fungal/carcinomas/viral/parasitic/bacterial infections.

Diagnosis:
• Screening: ELISA.
• Confirmation: Western blot / immunofluorescence.
• Detection of infection in newborns of HIV+ moms: DNA/PCR.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs Specialized Transduction

What's New?

Recently Added Pages: Popular Pages:
Hormonal Signaling Pathways Notes on Heart Muscle Mechanics
Notes on Electrical Activity of the Heart Notes on Heart Sounds and Murmurs
Notes on Diagnostic and Statistical Manual IV (DSM IV) Major Depressive Disorder vs Dysthymic Disorder
How to Stop Feedback Form & Guestbook Spam Pictures of old Kuwaiti Dinars
Body-Mass-Index, Waist-to-Height Ratio, Body Fat, Basal Metabolic Rate Calculator Digestion FAQ, Defecation reflex, etc.
Notes on Basic Gastrointestinal Physiology Inferential Statistics
Notes on Osteogenesis What is an ELEK's Test?
Why did I decide to become a doctor? Medical School Admissions Essay Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies What is Steady State Concentration?
Generalized vs Specialized Transduction Differentiation and Anatomy of a Blastocyst
Rahul's USMLE Downloads

You can also keep track of updates on RahulGladwin.com by subscribing to my RSS newsfeed. RahulGladwin RSS Feed

Here is a comprehensive list of all documents on RahulGladwin.com.

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.

Page accessed on: July 29, 2010, 11:42 am.

top Back to Top