Notes on DNA viruses

    Rahul's Noteblog     Notes on Virology     Notes on DNA viruses

All ds except parvovirus

Parvoviridae:
• ssDNA; naked icosahedral.
• Fifth disease; B-19 virus; erythema infectiosum = slapped cheek fever.
• Aplastic crisis in Sickle Cell patients.

Papovaviridae:
• dsDNA; naked icosahedral.
• Human papilloma virus; plantar warts; koilocytic cells found on Pap smear.
• Polyoma viruses: BK virus; JC virus.

Adenovirusis:
• dsDNA; naked.
• Upper respiratory infections in kids.
• Pharyngoconjunctivitis (pink eye / swimming pool conjunctivitis).
• Epidemic keratoconjunctivitis (shipyard conjunctivitis).
• Acute respiratory disease and pneumonia (young military recruits).
• Adenovirus 40/41: infantile diarrhea; adenovirus 12, 18, 31: normally present in human feces.

Herpesviridae:
• Enveloped; icosahedral; dsDNA.
• DNA synthesized in nucleus.
• Intranuclear inclusion bodies.
• Treatment: use Acyclovir.

HSV-1:
• Gingivostomatitis and recurrent cold sores; latent in trigeminal root ganglion.
• Keratoconjunctivitis: lid swelling and vesicles; visual impairment.
• Meningoencephalitis: fever, headache, confusion; diagnosis is RBCs in CSF.

HSV-2:
• Meningitis.
• Herpes genital infections: painful lesions on genitals and anal area; latent in sacral n. ganglia.
• Neonatal herpes.
• Diagnosis: PCR of CSF and viral culture with fluorescent Ab stain; Tzanck smear (outdated); immunoflorescent staining can differentiate between HSV-1 and 2.

Varicella-zoster:
• Chicken pox: latent in dorsal root ganglion.
• Reye's syndrome.
• Disseminated infections in IC hosts.
• Vaccine available; passive transfer of immunity with VZ immunoglobulin.

EBV:
• B cell infection; binds to CD21 = CR2.
• Infectious mononucleosis; kissing disease: fatigue, fever, sore throat, lymphadenpathy, and splenomegaly; Abs react with Paul-Bunnell antigen on sheep/bovine RBCs.
• Burkitt lymphoma, nasopharyngeal cancer, and thymus carcinoma; all contain EB Nuclear Angiten.

CMV:
• Herpesviridae infecting fibroblasts; owl's eyes.

• Human herpesvirus 6: exanthem subitum; roseola; infant disease; rash.
• Human herpesvirus 8: Kaposi sarcoma co-factor.

Poxviridae:
• Brick-shaped, large; ds linear DNA.
• Cytoplasm replication.

Variola:
• Small pox; Guarnieri bodies in infected cells.

Vaccinia: immunogen complex in smallpox vaccine.

Molluscum contagiosum: small, pink, wart-like tumors; eosinophilic cypoplasmic inclusion bodies; problem in IC hosts.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs Specialized Transduction

What's New?

Recently Added Pages:	Popular Pages:
Hormonal Signaling Pathways	Notes on Heart Muscle Mechanics
Notes on Electrical Activity of the Heart	Notes on Heart Sounds and Murmurs
Notes on Diagnostic and Statistical Manual IV (DSM IV)	Major Depressive Disorder vs Dysthymic Disorder
How to Stop Feedback Form & Guestbook Spam	Pictures of old Kuwaiti Dinars
Body-Mass-Index, Waist-to-Height Ratio, Body Fat, Basal Metabolic Rate Calculator	Digestion FAQ, Defecation reflex, etc.
Notes on Basic Gastrointestinal Physiology	Inferential Statistics
Notes on Osteogenesis	What is an ELEK's Test?
Why did I decide to become a doctor? Medical School Admissions Essay	Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case	My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values	Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies	What is Steady State Concentration?
Generalized vs Specialized Transduction	Differentiation and Anatomy of a Blastocyst
Notes on Cell Components	Notes on Nervous Tissue

You can also keep track of updates on RahulGladwin.com by subscribing to my RSS newsfeed.

Here is a comprehensive list of all documents on RahulGladwin.com.

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.

Page accessed on: September 10, 2010, 8:59 pm.

 Back to Top

Site Search

Main Menu