Notes on Negative sense RNA viruses

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(all enveloped)

Paramyxovirus:
• Helical.
• Mumps: parotitis, pancreatitis, orchitis, meningoencephalitis; live vaccine available.
• Measles/Rubeola: 3 Cs: Cough, coryza, conjunctivitis; giant cell pneumonia, Koplik spots from ears down; live vaccine available.
• RSV: bronchiolitis and pneumonia in infants; common cold.
• Parainfluenza: croup; common cold.

Rhabdovirus:
• Bullet shaped.
• Rabies: negri bodies seen - these are intracytoplasmic inclusion bodies.
• Vesicular stomatitis: foot and mouth disease.

Filovirus:
• Helical.
• Marburg; Ebola: acute hemorrhagic fever; frequently fatal.

Orthomyxovirus:
• Helical.
• Influenza: separate H and N glycoproteins.
• Complications: Guillain-Barre or Reye's syndrome.
• Genetic shift/drift.

Bunyavirus:
• Helical.
• California encephalitis, La Crosse encephalitis: mosquito-borne; young patients.
• Hantavirus: Hanta virus pulmonary syndrome; rodent feces.

Arenavirus:
• Helical.
• Lymphocytic choriomeningitis: South American.
• Lassa Fever: West Africa; hemorrhagic fever.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs Specialized Transduction

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