Notes on Negative sense RNA viruses

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Paramyxovirus:

• Helical.

• Mumps: parotitis, pancreatitis, orchitis, meningoencephalitis; live vaccine available.

• Measles/Rubeola: 3 Cs: Cough, coryza, conjunctivitis; giant cell pneumonia, Koplik spots from ears down; live vaccine available.

• RSV: bronchiolitis and pneumonia in infants; common cold.

• Parainfluenza: croup; common cold.

Rhabdovirus:

• Bullet shaped.

• Rabies: negri bodies seen - these are intracytoplasmic inclusion bodies.

• Vesicular stomatitis: foot and mouth disease.

Filovirus:

• Helical.

• Marburg; Ebola: acute hemorrhagic fever; frequently fatal.

Orthomyxovirus:

• Helical.

• Influenza: separate H and N glycoproteins.

• Complications: Guillain-Barre or Reye's syndrome.

• Genetic shift/drift.

Bunyavirus:

• Helical.

• California encephalitis, La Crosse encephalitis: mosquito-borne; young patients.

• Hantavirus: Hanta virus pulmonary syndrome; rodent feces.

Arenavirus:

• Helical.

• Lymphocytic choriomeningitis: South American.

• Lassa Fever: West Africa; hemorrhagic fever.

Note: All the above viruses are enveloped.

Additional Readings:

Basic Virology

1. Immune defences against viruses
2. Viral Hepatitis
3. DNA viruses
4. Positive-sense RNA viruses
5. Human Immunodeficiency Virus
6. Negative sense RNA viruses
7. Double stranded RNA Viruses
8. Viruses associated with cancer
9. Generalized vs specialized transduction
10. Hepatitis serologic markers
11. Bacterial vs viral infections
12. Human Immunodeficiency Virus (HIV) Infections and AIDS
13. Steps When Patient is Newly Diagnosed with HIV

Related Topics

1. Prenatal Infections

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