Hormonal Signaling Pathways

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Important Endocrine Receptors:

cAMP: FSH, LH, ACTH, TSH, CRH, hCG, ADH (V2 receptor), MSH, PTH, Glucagon, Calcitonin.
Steroid receptor: Glucocorticoid, Estrogen, Progesterone, Testosterone, Aldosterone, Vitamin D, T3/T4.
cGMP: ANP, NO (EDRF).
IP3: GnRH, GHRH, Oxytocin, ADH (V1 receptor), TRH, muscarinic acetylcholine receptor, alpha1, histamine1.
Tyrosine Kinase: Insulin, IGF-1, FGF, PDGF, Prolactin, GH.

MAP-Kinase vs JAK/STAT Pathway:

Receptor: With intrinsic enzyme activity (receptor tyrosine kinase) Without intrinsic enzyme activity (tyrosine kinase associted receptor)
Structure: Extracellular domain | Transmembrane domain | Cytosolic domain Extracellular domain | Transmembrane domain | Cytosolic domain
Signaling Pathway: MAP-Kinase | Ras JAK/STAT
Examples: EFG, PDFG, FGF, growth factor receptors Receptor for cytokines, growth hormone, prolactin, IL-2

Additional Reading:

Basic Endocrinology

1. Introduction to Endocrinology
2. Hypothalamic-pituitary system
3. Adrenal Hormones
4. Antidiuretic Hormone (ADH) and ECF Regulation
5. Endocrine Pancreas
6. Growth Hormone
7. Adrenal Medulla
8. Hormonal Control of Calcium and Phosphate
9. Thyroid Hormones
10. Hormones of Male Reproduction
11. Hormones of Female Reproduction
12. Fluid Compartments of the Body
13. Notes on Hypothalamus Anterior Pituitary and Thyroid
14. Additional Notes on Female Reproduction
15. Hormonal Signaling Pathways
16. FAQ on Adrenal Hormones
17. FAQ on Male Reproduction
18. Synthesis and Deficiencies of Adrenal Hormones
19. Significance of Glycosylated Hemoblogin (HbA1c)
20. Significance of Measuring Albumin while with Calcium Levels
21. Stepwise Approach to Treatment of Ascites
22. How to differentiate between Diabetes Insipidus vs Psychogenic Polydipsia

Related Topics

1. Histology of the Endocrine System
2. Histology of the Male Reproductive System
3. Histology of the Female Reproductive System

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