Notes on Acquired Immunodeficiency Syndrome

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Acquired Immunodeficiency Syndrome (AIDS):

• Attaches to CD4 receptors on host cells and enters them.

• Uses CCR5 chemokine receptors early in infection; macrophage tropic.

• Uses CXCR4 chemokine receptors late in the infection; T cell tropic.

Mechanism:

Nef gene downregulates MHC I.

Tat gene inhibits cytokine synthesis.

• Multiplication in lymphocytes and macrophages.

• Cytopathic effects on lymphocytes and macrophages.

• TH destroyed.

• Antigenic drift and glycosylation of gp120.

• Immune deviation toward TH2 response.

Macrophages and Dendritic Cells:

• Infected with HIV but resistant to destruction.

• Spread virus to lymphoid organs.

• Have impaired AP function.

Antibodies generated against HIV; used for diagnosis in ELISA, western blot, etc.

Additional Readings:

Basic Immunology

1. Introduction to Immunology
2. Cells of Immunology
3. Selection of Lymphocytes
4. Primary Response to Antigen
5. Antigen Processing and Presentation
6. Humoral Effector Mechanism Generator
7. Cell-Mediated Effector Mechanism Generator
8. Vaccination and Immunotherapy
9. Immunodeficiency Diseases
10. Acquired Immunodeficiency Syndrome
11. Hypersensitivities and Autoimmunity Diseases
12. Immunology of Transplantation
13. Immunology of Cancer
14. Immunology Laboratory Technology
15. Acquired Immunity
16. Type II Hypersensitivity Reaction
17. Hypersensitivity Reactions
18. Primary Immunodeficiency
19. Secondary Immunodeficiency
20. Type III Hypersensitivity Reaction
21. Type IV Hypersensitivity Reaction
22. Type V Hypersensitivity Reaction
23. Tumor Immunology
24. Images of Antibodies
25. Th1 vs Th2 cells

Related Topics

1. Histology of Lymphoid Tissue

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