Notes on Immunology of Cancer

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Tumors and Anti-tumor Mechanisms:

• Tumor cells are weakly immunogenic.

• Anti-tumor mechanisms: Cytotoxic T Lymphocytes, antibodies, macrophages, NK cells.

Cytotoxic T Lymphocytes:

• Major anti-tumor cells.

• Perform surveillance by recognizing molecules presented by MHC I.

Secondary Response to Tumors:

• Antibody-mediated killing.

Tumor cells escape destruction by:

• Decreasing MHC expression.

• Antigen-loss variants.

• TGF-beta inhibition of effector functions.

• FasL induced apoptosis.

• Tolerance of TCR.

• Antigens masked by mucopolysaccharides.

Additional Readings:

Basic Immunology

1. Introduction to Immunology
2. Cells of Immunology
3. Selection of Lymphocytes
4. Primary Response to Antigen
5. Antigen Processing and Presentation
6. Humoral Effector Mechanism Generator
7. Cell-Mediated Effector Mechanism Generator
8. Vaccination and Immunotherapy
9. Immunodeficiency Diseases
10. Acquired Immunodeficiency Syndrome
11. Hypersensitivities and Autoimmunity Diseases
12. Immunology of Transplantation
13. Immunology of Cancer
14. Immunology Laboratory Technology
15. Acquired Immunity
16. Type II Hypersensitivity Reaction
17. Hypersensitivity Reactions
18. Primary Immunodeficiency
19. Secondary Immunodeficiency
20. Type III Hypersensitivity Reaction
21. Type IV Hypersensitivity Reaction
22. Type V Hypersensitivity Reaction
23. Tumor Immunology
24. Images of Antibodies
25. Th1 vs Th2 cells

Related Topics

1. Histology of Lymphoid Tissue

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