Notes on Primary Response to Antigen

  >   Rahul's Noteblog   >   Notes on Immunology   >   Notes on Primary Response to Antigen


• Too small to induce immune response.

Extravasation of Phagocytes:

• Rolling, activation by chemoattractants (eg., IL-8, LTB4), arrest and adhesion, and transendothelial migration.

Leukocyte adhesion deficiency:

• Absence of CD18; leukocytes don't undergo adhesion; omphalitis, swelling and inflammation of umbilical cord.


• If antigen is coated with IgG or C3B, phagocytosis is 4000 times stronger.

Inside Macrophage:

• Respiratory burst.

NADPH Oxidase:

• Neutralizes superoxide; creates hydroxyl radical and hydrogen peroxide; oxygen-independent.


• Uses NADPH oxidase-produced hydrogen peroxide and chloride ion to create microbicidal hypochlorite; oxygen-dependent.

Chronic Granulomatous Disease (CGD):

• Deficient NADPH oxidase; person will be infected with catalase+ (but not catalase-) organisms.

• Oxygen-independent mechanism kills: catalase-positive organisms; oxygen-dependent mechanism kills: catalase-negative organisms.

Additional Readings:

Basic Immunology

1. Introduction to Immunology
2. Cells of Immunology
3. Selection of Lymphocytes
4. Primary Response to Antigen
5. Antigen Processing and Presentation
6. Humoral Effector Mechanism Generator
7. Cell-Mediated Effector Mechanism Generator
8. Vaccination and Immunotherapy
9. Immunodeficiency Diseases
10. Acquired Immunodeficiency Syndrome
11. Hypersensitivities and Autoimmunity Diseases
12. Immunology of Transplantation
13. Immunology of Cancer
14. Immunology Laboratory Technology
15. Acquired Immunity
16. Type II Hypersensitivity Reaction
17. Hypersensitivity Reactions
18. Primary Immunodeficiency
19. Secondary Immunodeficiency
20. Type III Hypersensitivity Reaction
21. Type IV Hypersensitivity Reaction
22. Type V Hypersensitivity Reaction
23. Tumor Immunology
24. Images of Antibodies
25. Th1 vs Th2 cells

Related Topics

1. Histology of Lymphoid Tissue

Medical Images

Useful Medical Images & Diagrams (link opens in a new window)

Random Pages:

What is Time? How to Stop Feedback Form & Guestbook Spam
Video of me playing Yanni`s "Nightingale" Notes on Lymphoid Tissue
Notes on Chest Wall Notes on Growth Medias and Oxygen Requirements
Notes on Glycogen, Gluconeogenesis, and Hexose Monophosphate Shunt What is Pulseless Electrical Activity?
FAQ on Adrenal Hormones Usage of the D-xylose Absorption Test
Notes on Basic Gastrointestinal Physiology Life in a Drop of Water
Review of Delta Roma Imperiale Fountain Pen What is an ELEK`s Test?
Why did I decide to become a doctor? Medical School Admissions Essay Video: Titanic Piano Theme: The Portrait
Corporate Failure: The Enron Case My Experience during the Iraqi Invasion of Kuwait
USMLE Blood Lab Values Regulation of Heart Rate by Autonomic Nervous System
Images of Antibodies Video of me playing Unknown Easy Blues Piano
Notes on Respiratory System Differentiation and Anatomy of a Blastocyst
Notes on Cell Components Notes on Nervous Tissue
Voices from Hell: My Experience in Mussoorie, India Video of Cardiology Examination in a Clinical Setting

Please Do Not Reproduce This Page

This page is written by Rahul Gladwin. Please do not duplicate the contents of this page in whole or part, in any form, without prior written permission.