Notes on Immunology of Transplantation

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What is a Human Leukocyte Antigen?

• HLA is co-dominant.

• Each individual inherits HLA from both parents.

• Two different individuals are very different in terms of HLA.

• Leads to graft rejection.

Transplant Rejection:

• CD4+ and CD8+ cells from host cell initiate attack against transplanted tissue.

• TH cytokines stimulate macrophages, cytotoxic cells, and anti-body-mediated killing.

• MHC I expression increased due to TNF-alpha and beta, and IFN-gamma.

Graft-vs-host disease:

• Remove T-cells from bone marrow before transplanting it.

• T cells from donor bone marrow attack MHC from recipient, and cause widespread damage.

• Rash, jaundice, diarrhea, GI hemorrhage.

Additional Readings:

Basic Immunology

1. Introduction to Immunology
2. Cells of Immunology
3. Selection of Lymphocytes
4. Primary Response to Antigen
5. Antigen Processing and Presentation
6. Humoral Effector Mechanism Generator
7. Cell-Mediated Effector Mechanism Generator
8. Vaccination and Immunotherapy
9. Immunodeficiency Diseases
10. Acquired Immunodeficiency Syndrome
11. Hypersensitivities and Autoimmunity Diseases
12. Immunology of Transplantation
13. Immunology of Cancer
14. Immunology Laboratory Technology
15. Acquired Immunity
16. Type II Hypersensitivity Reaction
17. Hypersensitivity Reactions
18. Primary Immunodeficiency
19. Secondary Immunodeficiency
20. Type III Hypersensitivity Reaction
21. Type IV Hypersensitivity Reaction
22. Type V Hypersensitivity Reaction
23. Tumor Immunology
24. Images of Antibodies
25. Th1 vs Th2 cells

Related Topics

1. Histology of Lymphoid Tissue

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