Notes on Bordetella

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Genus: Bordetella.

• Small G- strict aerobes.

Bordetella pertussis:

• Grows on: Regan-Lowe or Bordet-Gengou media.

• Direct immunoflorescence on nasopharyngeal smear.

• Capsule.

• Found in respiratory tract; transmitted by respiratory droplets.

Pathogenesis:

• Attaches to nasopharyngeal mucosal ciliated epithelial cells with aid of pertussis toxin.

Mechanism of Bordetella Toxins:

• Adenylate cyclase: inhibits phagocytosis.

• Tracheal cytotoxin: interferes with ciliary action.

• Pertussis toxin: ADP ribosylation of Gi.

Disease:

Whooping Cough:

• Catarrhal (1-2 weeks);

• Paroxysmal (2-4 weeks);

• Convalescence (>3 weeks).

Treatment:

• Erythromycin.

Additional Readings:

Basic Bacteriology

1. Bacterial Locations and Toxins
2. Growth Medias and Oxygen Requirements
3. Staphylococus
4. Streptococcus
5. Enterococcus
6. Bacillus
7. Listeria
8. Corynebacterium
9. Actinomyces
10. Nocadria
11. Mycobacterium
12. Clostridium
13. Neisseria
14. Pseudomonas
15. Legionella
16. Bordetella
17. Francisella
18. Brucella
19. Campylobacter
20. Escherichia
21. Shigella
22. Klebsiella
23. Salmonella
24. Yersinia
25. Proteus
26. Vibrio
27. Pasteurella
28. Haemophilus
29. Bacteriodes and Prevotella
30. Treponema
31. Borrelia
32. Rickettsia
33. Coxiella
34. Ehrlichia
35. Chlamydia
36. Mycoplasma
37. What is an ELEK's Test?
38. Causes of Orchitis
39. What is Leprosy?
40. What is Folliculitis?
41. What is Botulism?
42. How to interpret PPD (Purified Protein Derivative) results?
43. Prenatal Infections

Related Topics

1. Bacterial vs viral infections

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